Title : Phytomedicinal compounds from the wild grape Ampelocissus latifolia
Abstract:
Vitaceae, also known as Grape family has many plants with dietery, medicinal, and industrial significance. Some important medicinal plants of the family include, Cissus quadrangularis, Cissus repanda, Cayratia trifolia, Ampelocissus latifolia , all having various health benefits especially in bone health. Most of them are used in bone healing especially C. quadrangularis, which is locally known as” hadjod” meaning Bone joiner. The in vitro callus has been raised and maintained on MS medium supplemented with growth regulators. . The plant Ampelocissus latifolia, also known as wild grape has many medicinal properties and is used for curing simple body aches and fever to highly complicated disorders and bone fractures. In vivo and in vitro studies have been done in the plant and it was found to be rich in phytochemicals and metabolites. Further biochemical studies like GC-MS, FTIR and HPTLC revealed the presence of various important plant metabolites like beta-sitosterol, Campesterol, Stigmasterol, Caryophyllene, Tocopherol, Squalene, Bergamol, Behenylbehenate, Betulin, Longifolene, Ergosterol, 5-Hydroxy methyl furfural etc. The bioactive secondary metabolites such as flavonoid daidzein and terpenoid lupeol have been identified, isolated and quantified from different plant parts using HPTLC. Daidzein has been reported as both a phytoestrogen and antioxidant, and it is most often used to treat conditions affected by a decrease in estrogen levels in the body like menopause, including osteoporosis and increased risk of heart disease. These plant based estrogens are devoid of harmful side effects. Lupeol has various pharmacological activities displaying anti-protozoal, anti-microbial, anti-inflammatory, antitumor and chemo-preventive properties. Various functional groups of different activities have been identified through FTIR spectroscopy. They also possess high antioxidant and antimicrobial activity which can be correlated with their medicinal value.
