Title : Plant-derived bioactive compounds, multi-omics integration, and polypharmacology: A b-phytopharma and b-bioinformatics framework
Abstract:
Plant-derived bioactive compounds play an important role in medicinal plant research, phytopharmacology, nutrition, inflammation modulation, antioxidant response, anticancer mechanisms, and integrative pharmacology. However, their biological effects are rarely limited to a single molecule, single target, or single pathway. Herbal and plant-derived compounds often act through multi-target modulation, synergistic interactions, metabolic transformation, tissue-specific, and system-level biological response. This presentation proposes a b-phytopharma and b-bioinformatics framework for interpreting plant-derived bioactive compounds through multi-omics integration, polypharmacology, and systems-level biological modeling. The proposed framework connects phytochemical composition, secondary metabolite production, plant stress physiology, compound–target interaction, DNA–phytochemical interaction, protein and pathway modulation, herb–drug interaction, and bioavailability within a unified interpretive structure. B-phytopharma is used to model phytochemical pharmacology, herbal synergy, synthetic–herbal drug comparison, anti-inflammatory and antioxidant mechanisms, and ADME-related transport behavior. B-bioinformatics is used to support geometry-aware analysis of omics data, including genomics, transcriptomics, proteomics, metabolomics, sequence-to-structure mapping, protein–protein interaction networks, gene regulatory systems, and spatial or temporal biological programs. The presentation highlights how plant-derived compounds may be studied not merely as isolated chemical entities, but as dynamic biological modulators acting across molecular, cellular, tissue, and systemic scales. Multi-omics evidence may be used to connect phytochemical exposure with gene expression, protein response, metabolic alteration, pathway regulation, and disease-relevant biological state transitions. Polypharmacology is interpreted as coordinated multi-target action, while herbal formulation variability is considered through composition consistency, standardization, batch variability, and interaction geometry. Through bvidal clinical software suite (which is a SaMD, Software as a medical device), the proposed b-phytopharma and b-bioinformatics framework can be demonstrated as a research-oriented SaMD workflow for organizing and interpreting plant-derived bioactive compounds in relation to biological targets, multi-omics evidence, disease pathways, pharmacological response, and safety monitoring.
