Title : Eco-innovative formulation of Folic Acid Coated Pea Pods-based Phytosomes (FPPbP): A sustainable approach against cancer
Abstract:
Cancer treatment continues to face challenges such as poor drug targeting, side effects, and limited bioavailability of therapeutic agents. In response, this study explores a sustainable and innovative approach by developing folic acid–coated phytosomes derived from pea pod extracts. Pea pods, often considered agricultural waste, are rich in bioactive phytochemicals with potential anticancer properties, making them an eco-friendly and cost-effective resource. The formulation of phytosomes enhances the stability and absorption of these plant-derived compounds, while folic acid coating facilitates targeted delivery to cancer cells, which commonly overexpress folate receptors. This dual strategy not only improves therapeutic efficiency but also minimizes damage to healthy tissues. The prepared system will be evaluated for its physicochemical characteristics, stability, and in vitro anticancer activity. Hypothesis is made that the formulated phytosomes will exhibit improved bioavailability, controlled release behavior, and promising cytotoxic effects against cancer cell lines compared to conventional extracts. The use of biodegradable materials and waste-derived resources further, will highlight the environmental and economic benefits of this approach. Overall, this study presents a human-centered and environmentally responsible strategy that integrates green chemistry with advanced drug delivery systems that could serve as a potential candidate for safer and more effective cancer therapy, while also promoting sustainability in pharmaceutical development.
