Title : The activities of compounds from Hyptis suaveolens and Momordica charantia against the aetiological agents of human and animal African Trypanosomiasis
Abstract:
African trypanosomiasis is a significant health challenge to humans and livestock in Africa and new drugs to combat this disease are needed. Leaves of Hyptis suaveolens and Momordica charantia were extracted and subjected to silica gel column chromatography. Structures of isolated compounds were elucidated through NMR and HR-EIMS spectrometry. The effect of biomolecules assay of isolated compounds against trypomastigotes of Trypanosoma brucei brucei S247 and T. congolense IL3000 were evaluated. Callistrisic acid, dehydroabietinol, suaveolic acid, suaveolol, and a mixture of suaveolol and suaveolic acid were obtained from H. suaveolens while karavilagenin D and momordicin I acetate were obtained from M. charantia. The compounds tested had promising values with EC50 for suaveolol: 2.71±0.36 µg/ml (8.84±1.18 µM), and 1.56±0.17 µg/ml (2.55 ±0.41µM) on T. b. brucei trypomastigotes, and moderate activities was observed for suaveolic acid: 11.14±0.54 µg/ml (34.76±1.69 µM) against T. congolense trypomastigotes. In conclusion, suaveolol and its mixture with suaveolic acid possessed significant and selective antitrypanocidal activity.
Keywords: African trypanosomiasis, plants, compounds, NMR
Audience Takeaway:
- Neglected Tropical Diseases
- Natural products
- Compounds Isolated from Natural Products
