Title : Extraction and identification of bioactive compounds from organic White Mugwort (Artemisia lactiflora Wall.)
Abstract:
White mugwort (Artemisia lactiflora Wall.) is an edible medicinal plant from traditional Chinese medicine which has been subjected of considerable attention due to their remarkable biological activities such as antitumor and antioxidant activity. In Thailand, the aerial part of this plant is commonly consumed to treat and prevent diseases, especially cancer. Although there is no clear scientific evidence on its anticancer and other biological activities, this plant provides innumerable health benefits due to the containing phytochemicals. To date, there are limited research investigating on the phytochemical constituents and bioactivity of this plant. Therefore, the aim of this study was to identify the polyphenol compounds in organic white mugwort and investigate on biological activities of its extracts. In the present study, three main phenolic compounds i.e., gallic acid, isoquercetin and quercetin, were identified in fresh aerial part extract (FE) and dried powder extract (PE) from white mugwort obtained by HPLC-DAD. Pro-inflammatory genes were down-regulated in LPS-stimulated THP-1 treated with PE indicating anti-inflammatory activity. FE and PE decreased lipid accumulation of 3T3-L1. FE showed a stronger cytotoxicity on 4 cholangiocarcinoma cell lines (KKU-M213, HuCCA-1, RMCCA-1, and KKU-M055) than those of PE. As a result, white mugwort is a prominent source of natural antioxidants exhibiting underline health benefits.
