HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.
September 16-18, 2024 | Rome, Italy
GPMB 2018

Hong Wei Xue

Hong Wei Xue, Speaker at Plant Biology Conferences
Chinese Academy of Sciences, China
Title : Proteasome regulation in plant development


The ubiquitin/26S proteasome proteolytic pathway selectively removes regulatory proteins, providing an efficient and rapid strategy to control many cellular processes and plays critical roles in protein removal in mammalian and plant cells. The proteasome is highly conserved and it has been shown that the bovine proteasome inhibitor 31 (PI31) and its homologues in mouse and humans diminish the activity of purified 20S proteasome; however, still little is known how proteasome activity is regulated in either mammals or plants. Through systemic genetics studies, we showed that an Arabidopsis homologue of the proteasome inhibitor PI31, which was designated as PROTEASOME REGULATOR1 (PTRE1), is a positive regulator of the 26S proteasome. Loss-of-function ptre1 mutant presents growth defect in multiple processes, and interesting, ptre1 is insensitive to auxinmediated suppression of proteasome activity. Further studies showed that auxin alters the subcellular localization of PTRE1, indicating this may be part of the mechanism by which it reduces proteasome activity and auxin regulates proteasome activity via PTRE1 to fine-tune the homoeostasis of Aux/IAA repressor proteins thus modifying auxin activity. Our further studies indicated that various factors modulate PTRE1 activity to involve the regulation of hormone signaling including gibberrllin and brassinotgeroids, and plant thermotolerance, which will be presented. As proteasome and whose activity control are involved in various developmental and stress-related processes, there should be possible links with the researches at different fields.


Hong-Wei Xue was issued the Bachelor and Doctorial degree in 1991 and 1996, from East-China Normal University and Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, respectively; then went to the MaxPlanck-Institute of Molecular Plant Physiology, Germany for postdoctoral research (1996-1998). Dr. Xue was back Shanghai Institute of Plant Physiology and Ecology, SIBS, CAS in 1999. He has served as the deputy Director (2005- 2009) and Director (2009-2014) of the Shanghai Institute of Plant Physiology and Ecology, and Director of the National Key Laboratory of Plant Molecular Genetics (2006-2017). Currently Dr. Xue is the principal investigator and serves as the member of the editorial board of Plant Physiology (2011-present); Molecular Plant (2008-present); Cell Research (2006-present). The main interests of Xue’s group include: 1) functional mechanisms of auxin and protein phosphorylation in hormone effects, and 2) genetics and epigenetics regulation of rice seed development. He has published more than 40 papers in Nature Communications, EMBO J, Plant Cell, Cell Research, Cell Reports, etc. and was invited for review articles in Current Opinion of Plant Biology and Biochemical J