In the last decade, marine macroalgae (or seaweeds) have emerged as the most promising renewable bioresource to produce distinct valuable products. The distinctive advantages of high growth rate, CO2 sequestration potential, no arable land, and freshwater requirement have made seaweeds a demanding feedstock for several biobased products. Traditionally, macroalgae have been utilized to extract a single bioproduct in a direct extraction which left huge biomass chunks as a waste. However, with the introduction of biorefinery, the macroalgae now can be used to extract multiple value-added products in a sequential process with negligible leftover residues. The biorefinery design makes the process economically viable and opens a window for seaweed-based startups. Nevertheless, the macroalgal biorefinery concept with advanced technology involvement has revolutionized a part of the global economy to be the seaweed global green-circular economy. Therefore, the talk would mainly focus on the different zero waste management strategies to utilize the complete macroalgal biomass (from fresh to residue) by producing various primary and secondary products, a possible seaweed biorefinery-based economical model, and recent advances in macroalgal biotechnology.