Antimicrobial agents have protected us from various infections caused by bacteria, viruses, fungi, protozoans, and others for over 100years now. Antibiotics are becoming ineffective because of overuse, misuse, or abuse. The increasing incidence of antimicrobial resistance on a global scale is threatening. It is jeopardizing the healthcare sector, food industry with other detrimental effects. Many experts suggest that antimicrobial peptides (AMPs) could be next- generation antibiotics. Initially, the AMPs against bacteria were focused on food preservation. However, recently the applications of bacteriocins have been expanded to human health as a therapeutic agent. Multiple studies have proven that bacteriocins can play a multifaceted role in microbial ecology by controlling the emerging drug-resistant pathogens. The diverse functions contributed by AMPs against many microbial groups are manifesting its multidimensional applications for human welfare. Our research is on a bacteriocin that was isolated from an ethnomedicinal plant microbiome originated strain of Bacillus subtilis (MK733983). Its molecular weight is estimated to be 3.4KDa. Its action mechanism is by membrane pore-forming, and all these observations were made using the scanning electron microscope. It is non-hemolytic, non- cytotoxic, exhibited commendable synergistic potential with 9 frontline antibiotics, and anti- biofilm potential. It is patented research and a work in progress.
Audience TAke Away Notes:
My field of research is to find solutions for a looming global threat, antimicrobial resistance (AMR) from natural sources, such as Plants. Unfortunately, many educated people do not realize the seriousness of the risk caused due to antimicrobial resistance. My message can re-emphasize this subject even among the learned society.
Antimicrobial peptides are proving to be a potential solution to AMR, and I sincerely feel we need more researchers to come up in this field to fasten the discoveries. Evoking such a response among a few audiences can be a great gain.
The answer to the question ‘Is this research that other faculty could use to expand their research or teaching?’ is definitely yes.
Witnessing the research topic first-hand, which is a potential solution to combat AMR is a good opportunity.